How can I install multiple HP-UX patches, without having to reboot more than once?

Use swcopy(1M) on each patch to copy the patch into a local
depot, then use swinstall(1M) to install all patches
contained in the local depot.

# swcopy -s /tmp/PHCO_12345.depot \
 -x enforce_dependencies=false \* \
 @ /tmp/my_patch_depot
# swcopy -s /tmp/PHCO_67890.depot \
 -x enforce_dependencies=false \* \
 @ /tmp/my_patch_depot

etc..

# swinstall -s /tmp/my_patch_depot -x autoreboot=true \*

The following script automates the process of creating the
depot:

#!/sbin/sh
# cd to the directory where the patches are (PHxx_xxxx)
# and start this script. it will extract the patches one
# by one and create a patch-depot in $PDEPOT.

PATH=/usr/bin:/usr/sbin
PDEPOT=/tmp/my_patch_depot
for PFILE in PH*[0-9]; do
sh $PFILE
rm $PFILE
done
# It's a good habit first reading the PHxx_xxxx.text
# files before deleting them.
# rm *.text
for PFILE in PH*depot; do
swcopy -s -x enforce_dependencies=false $PWD/$PFILE \* \
@ $PDEPOT
done
clear
echo \
"*******************************************************"
echo \
"PLEASE NOTE: The Patch depot $PDEPOT has been created."
echo \
"*******************************************************"
echo \
"Please start swinstall with $PDEPOT as the source, and"
echo \
"don't forget to unregister the depot"
echo \
"(e.g. swreg -u -l depot $PDEPOT)."


Reference:
http://www.faqs.org/faqs/hp/hpux-faq/section-159.html